Sulfonation and Molecular Action
نویسندگان
چکیده
منابع مشابه
Sulfonation and molecular action.
The sulfonation of endogenous molecules is a pervasive biological phenomenon that is not always easily understood, and although it is increasingly recognized as a function of fundamental importance, there remain areas in which significant cognizance is still lacking or at most minimal. This is particularly true in the field of endocrinology, in which the sulfoconjugation of hormones is a widesp...
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Monoamine neurotransmitters are among the hundreds of signaling small molecules whose target interactions are switched "on" and "off" via transfer of the sulfuryl-moiety (-SO3) from PAPS (3'-phosphoadenosine 5'-phosphosulfate) to the hydroxyls and amines of their scaffolds. These transfer reactions are catalyzed by a small family of broad-specificity enzymes-the human cytosolic sulfotransferase...
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The tensile properties of sulfonated polyoxadiazoles have been studied as a function of molecular weight and sulfonation level. All sulfonated polyoxadiazoles synthesized through a polycondensation reaction of the hydrazine sulphate salt and a dicarboxylic acid in poly(phosphoric acid) exhibit rigid-ductile behavior with high Young’s modulus (3-4 GPa) and with larger elongations at break (up to...
متن کاملConvenient Regioselectivemono - 2 - O - Sulfonation
rides consisting of six or more cr-1,4-linked Dglucopyranose units which possess primary hydroxyl groups at the C-6 positions and secondary hydroxyl groups at the C-2 and C-3 positions. Because cyclomaltooligosaccharides have a hydrophobic and optically active interior, they have been utilized as transporters of hydrophobic molecules and as small molecular mimics of enzymes. One of the cyclomal...
متن کاملAntirachitic sulfonation of some steroids.
A few sterols, some derivatives, and certain steroid materials have been transformed chemically, by heating with suitable reagents (l-4), to products having antirachitic activity. This activating reaction1 involves heating an appropriate substrate in acetic acid solution with an efficient sulfonating reagent under anhydrous conditions for a number of hours. At the termination of the reaction ti...
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ژورنال
عنوان ژورنال: Endocrine Reviews
سال: 2002
ISSN: 0163-769X,1945-7189
DOI: 10.1210/er.2001-0040